Journal
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
Volume 10, Issue 4, Pages 272-283Publisher
WILEY-LISS
DOI: 10.1002/mrdd.20041
Keywords
autism; linkage; genetics; cytogenetics; language; microarray
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Autism is a heritable disorder characterized by phenotypic and genetic complexity. This review begins by surveying current linkage, gene association, and cytogenetic studies performed with the goal of identifying autism disease susceptibility variants. Though numerous linkages and associations have been identified, they tend to diminish upon closer examination or attempted replication. The review therefore explores challenges to current methodologies presented by the complexities of autism that might underlie some of the current difficulties, and finishes by describing emerging phenotypic, statistical, and molecular investigational approaches that offer hope of overcoming those challenges. (C) 2004 Wiley-Liss, Inc.
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