Journal
BLOOD
Volume 103, Issue 1, Pages 133-135Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2003-06-2101
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Funding
- NCI NIH HHS [T32CA09126-25, CA72769] Funding Source: Medline
- NHLBI NIH HHS [HL70813, HL70738] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [T32CA009126, R01CA072769] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL070738, R21HL070813] Funding Source: NIH RePORTER
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The murine adult hematopoietic stem cell is able to function as a hemangioblast, contributing both to blood reconstitution and to blood vessel repair in response to ischemic injury. We developed a novel mouse xenotransplantation model of retinal neovascularization to test human hematopoietic cell plasticity. Immunocompromised nonobese diabetic (NOD)/scid mice underwent myeloablative conditioning and transplantation with human CD34(+) umbilical cord blood. After multilineage reconstitution was established, retinal ischemia was induced to promote neovascularization. Our results demonstrate human retinal neovascularization, thus revealing the functional hemangioblast activity of human hematopoietic cells.
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