Journal
CATALYSIS COMMUNICATIONS
Volume 27, Issue -, Pages 38-43Publisher
ELSEVIER
DOI: 10.1016/j.catcom.2012.06.017
Keywords
Curcumin; Chitosan; Biodegradable catalyst; Curcumin 3,4-dihydropyrimidinone; Multi-component reaction
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Funding
- M.P.C.S.T. Bhopal [4468/CST/RD/2010]
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An efficient procedure for the synthesis of curcumin 3,4-dihydropyrimidinones has been developed by simple one-pot condensation of curcumin, aromatic aldehydes and urea/thiourea in the presence of commercially available chitosan in 2% acetic acid in aqueous media at 60 degrees C for 80-90 min. In the reaction, curcumin: a potential biologically active molecule has been used as a component of multi-component synthesis using chitosan as an efficient biodegradable and recyclable green catalyst. The resultant product curcumin 3,4-dihydropyrimidinone is formed in excellent yield (97%). The chitosan catalyst can be reused for without. loss of catalytic activity. (C) 2012 Elsevier B.V. All rights reserved.
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