4.6 Article

Natural alkaloids for copper-catalyzed N-arylation of amines and nitrogen-containing heterocycles

Journal

CATALYSIS COMMUNICATIONS
Volume 10, Issue 3, Pages 341-346

Publisher

ELSEVIER
DOI: 10.1016/j.catcom.2008.09.022

Keywords

Halides; Nucleophiles; Copper; Cross-coupling; Heterocycles

Funding

  1. Natural Science Foundation of Education Committee of Jiangsu Province [06KJB150099]
  2. Natural Science Foundation of China [20802046]
  3. Key Laboratory of Organic Synthesis of Jiangsu Province

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An efficient and readily available catalyst system Cu(OAc)(2)center dot H2O/(-)-sparteine has been developed for N-arylation of amines and nitrogen-containing heterocycles with aryl iodides, bromides, and chlorides, providing the corresponding products with moderate to good yields (up to 99%). (C) 2008 Elsevier B.V. All rights reserved.

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