Journal
EPILEPSIA
Volume 45, Issue -, Pages 48-56Publisher
WILEY
DOI: 10.1111/j.0013-9580.2004.04011.x
Keywords
current source density; epilepsy; human neocortex; interictal spikes; multiple unit activity
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Funding
- NINDS NIH HHS [R01 NS044623, R01 NS018741, NS18741, NS44623] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS044623, R01NS018741] Funding Source: NIH RePORTER
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Multicontact microelectrodes were chronically implanted in epilepsy patients undergoing subdural grid implantation for seizure localization. Current source density and multiple unit activity of interictal spikes (IISs) were sampled every similar to150 mum in a line traversing all layers of a cortical column. Our data suggest that interictal epileptiform events in humans are initiated by large postsynaptic depotarizations, consistent with the hypothesis that human IISs correspond to animal paroxysmal depolarization shifts. Furthermore, the cortical layer where the initial depolarization occurs may differ according to whether the IIS is locally generated or propagated from a distant location, and among the propagated IISs, whether the IIS is in the direct path of propagation or on the periphery of that path.
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