Journal
CATALYSIS COMMUNICATIONS
Volume 9, Issue 1, Pages 117-119Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.catcom.2007.05.030
Keywords
ruthenium; asymmetric catalysis; enamide hydrogenation
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The enantioselective hydrogenation of a challenging enamide (N-(3,4-dihydro-2-naphthalenyl)-acetamide, 1) bearing an endocyclic trisubstituted carbon-carbon double bond has been performed using cis-fac-Delta-[(RuCl)-Cl-II{(R)-(bpea)}{(S)-(BINAP)}]BF4, cis-fac-Delta-(R)(S)-3, as catalyst achieving good conversions and enantioselectivities up to 74%. Furthermore, the study of the influence of different reaction parameters during the hydrogenation reaction has been performed, showing a strong influence of the coordinating ability of the solvent on the reaction rate. (c) 2007 Elsevier B.V. All rights reserved.
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