4.7 Article

Hydroamination/Heck reaction sequence for a highly regioselective one-pot synthesis of indoles using 2-chloroaniline

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 24, Pages 2824-2825

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b411571f

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A one-pot indole synthesis consisting of a highly regioselective TiCl4-catalyzed hydroamination and a 5-endo Heck cyclization starting from 2-chloroaniline is described, using an in-situ generated, sterically hindered imidazol-2-ylidene palladium complex.

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