4.7 Article

Site-specific oxidative cleavage of DNA by metallosalen-DNA conjugates

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 21, Pages 2468-2469

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b410493e

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Funding

  1. NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR013810] Funding Source: NIH RePORTER
  2. NCRR NIH HHS [S10 RR13810] Funding Source: Medline
  3. NIGMS NIH HHS [GM08382] Funding Source: Medline

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Ni-salen-DNA conjugates, prepared by template-directed synthesis, targeted oxidative adduct formation and strand scission at deoxyguanosine sites in complementary DNA strands of Watson-Crick duplexes.

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