Journal
JOURNAL OF VIROLOGY
Volume 78, Issue 1, Pages 136-145Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.1.136-145.2004
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Funding
- Biotechnology and Biological Sciences Research Council [BBS/E/I/00001025] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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Production of alpha/beta interferon in response to viral double-stranded RNA (dsRNA) produced during viral replication is a first line of defense against viral infections. Here we demonstrate that the E-rns glycoprotein of the pestivirus bovine viral diarrhea virus can act as an inhibitor of dsRNA-induced responses of cells. This effect is seen whether E-rns is constitutively expressed in cells or exogenously added to the culture medium. The E-rns effect is specific to dsRNA since activation of NF-kappaB in cells infected with Semliki Forest virus or treated with tumor necrosis factor alpha was not affected. We also show that E-rns contains a dsRNA-binding activity, and its RNase is active against dsRNA at a low pH. Both the dsRNA binding and RNase activities are required for the inhibition of dsRNA signaling, and we discuss here a model to account for these observations.
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