4.7 Article

Novel C-C bond formation through addition of ammonium ylides to arylaldehydes: a facile approach to beta-aryl-beta-hydroxy alpha-amino acid frameworks

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 21, Pages 2486-2487

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b407449a

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Ammonium ylides generated in situ from alpha-diazo esters and amines in the presence of catalytic Rh-2(OAc)(4), undergo an aldol-type reaction with aldehydes affording highly substituted amino acid frameworks in a convergent, three-component reaction.

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