Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 146, Issue 1-2, Pages 144-152Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2003.11.004
Keywords
multiple sclerosis; experimental autoinumme encephalomyelitis; males; androgens; testosterone
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI050839] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS036680, R01NS045443] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI50839] Funding Source: Medline
- NICHD NIH HHS [HD07228] Funding Source: Medline
- NINDS NIH HHS [NS45443, NS36680] Funding Source: Medline
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A gender difference prevails in some murine strains of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). Our results showed that castration of SJL males, a strain characterized by decreased susceptibility of males as compared to females, displayed increased disease severity. In contrast, castration had no effect on disease in C57BL/6 males, a strain in which no gender difference in EAE is observed. Regardless of whether endogenous androgens were protective in a given genetic background, supplemental androgen treatment was protective in gonadally intact males of both strains. These data provide a basis for the novel therapeutic use of supplemental testosterone for men with MS. (C) 2003 Elsevier B.V. All rights reserved.
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