Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 146, Issue 1-2, Pages 203-208Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2003.10.032
Keywords
beta-chemokines; CD40/CD40L; blood-brain barrier; CNS
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beta-chemokines play an important role during the course of central nervous system (CNS) inflammation. Using primary cultures of human cerebral microvascular endothelial cells, we detected increased monocyte chemoattractant protein-1 (MCP-1) and regulated upon activation normal T cell expressed and secreted (RANTES) production following incubation with soluble CD40L. These results suggest a potential mechanism by which activated CD40L positive T cells may enhance beta-chemokine expression and thus influence the recruitment of mononuclear cells across the human blood-brain barrier. (C) 2003 Elsevier B.V. All rights reserved.
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