Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 146, Issue 1-2, Pages 1-12Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2003.10.041
Keywords
inflammation; mast cells; stress; vascular permeability
Categories
Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI019736] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR047652] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK062861, R01DK044816, R01DK042409] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS038326] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI 19736] Funding Source: Medline
- NIAMS NIH HHS [AR47652, R01 AR047652] Funding Source: Medline
- NIDDK NIH HHS [DK62861, DK42409, DK44816] Funding Source: Medline
- NINDS NIH HHS [NS38326] Funding Source: Medline
Ask authors/readers for more resources
Mast cells are not only necessary for allergic reactions, but recent findings indicate that they are also involved in a variety of neuroinflammatory diseases, especially those worsened by stress. In these cases, mast cells appear to be activated through their Fc receptors by immunoglobulins other than IgE, as well as by anaphylatoxins, neuropeptides and cytokines to secrete mediators selectively without overt degranulation. These facts can help us better understand a variety of sterile inflammatory conditions, such as multiple sclerosis (MS), migraines, inflammatory arthritis, atopic dermatitis, coronary inflammation, interstitial cystitis and irritable bowel syndrome, in which mast cells are activated without allergic degranulation. (C) 2003 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available