Journal
NEUROSCIENCE
Volume 129, Issue 3, Pages 509-519Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2004.07.052
Keywords
learned helplessness; behavioral depression; anxiety; stress; urocortin
Categories
Funding
- NIDA NIH HHS [DA13159] Funding Source: Medline
- NIMH NIH HHS [MH50479] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R37MH050479, R01MH050479] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA013159] Funding Source: NIH RePORTER
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The intra dorsal raphe nucleus (DRN) administration of corticotropin releasing hormone (CRF) inhibits serotonergic (5-HT) activity in this structure, an effect blocked by antagonists selective for the type 1 CRF receptor (CRF1). The DRN has a high density of the type 2 receptor (CRF2), and so the present experiments explored the impact of CRF2 activation within the DRN on 5-HT function. The intra-DRN administration of the selective CRF2 agonist urocortin 2 (Ucn 2) dose dependently increased 5-HT efflux in the basolateral amygdala, a projection region of the DRN. Intra-DRN Ucn 2 also increased c-fos expression in labeled 5-HT neurons. Both of these effects of Ucn 2 were completely blocked by intra-DRN antisauvagine-30 (ASV-30), a relatively selective CRF2 antagonist. These data suggest that CRF, and CRF2 activation within the DRN affect 5-HT neurons in opponent fashion. Implications of these results for understanding the behavioral effects of CRF and other CRF-like ligands are discussed. (C) 2004 IBRO. Published by Elsevier Ltd. All rights reserved.
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