Journal
DIABETES CARE
Volume 27, Issue 1, Pages 239-246Publisher
AMER DIABETES ASSOC
DOI: 10.2337/diacare.27.1.239
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OBJECTIVE - To comprehensively review the progress to date on the development of alternative routes for insulin delivery. RESEARCH DESIGN AND METHODS - Study data were collected through a Medline review. RESULTS - Proof of principle has been established for many routes of administration including dermal, nasal, oral, buccal, and pulmonary insulin delivery. CONCLUSIONS - Of all the approaches to date, pulmonary delivery appears to be most feasible. Ongoing phase III studies will ultimately determine safety, tolerability, and efficacy before approval for clinical use.
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