Journal
BIOMATERIALS
Volume 25, Issue 2, Pages 239-245Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(03)00494-0
Keywords
Si-DLC; Raman spectroscopy; haemocompatibility; contact angle/surface energy; work function/semi-conduction; human platelet aggregation
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We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electron spectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of < 0.05. (C) 2003 Elsevier Ltd. All rights reserved.
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