Journal
ANNALS OF NEUROLOGY
Volume 55, Issue 1, Pages 113-118Publisher
WILEY-LISS
DOI: 10.1002/ana.10782
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Funding
- PHS HHS [A69900, A617586, A610125] Funding Source: Medline
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Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.
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