Advances in functional and structural MR image analysis and implementation as FSL

The techniques available for the interrogation and analysis of neuro-imaging data have a large influence in determining the flexibility, sensitivity, and scope of neuro-imaging experiments. The development of such methodologies has allowed investigators to address scientific questions that could not previously be answered and, as such, has become an important research area in its own right. In this paper, we present a review of the research carried out by the Analysis Group at the Oxford Centre for Functional MRI of the Brain (FMRIB). This research has focussed on the development of new methodologies for the analysis of both structural and functional magnetic resonance imaging data. The majority of the research laid out in this paper has been implemented as freely available software tools within FMRIB's Software Library (FSL). (C) 2004 Elsevier Inc. All rights reserved.