Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 48, Issue 1, Pages 337-339Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.1.337-339.2004
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The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV.
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