Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 2, Issue 19, Pages 2814-2820Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b410240a
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The synthesis and associated structure - activity relationships for gene transfection of a series of spermine-derived cationic gemini surfactants incorporating diamino acid headgroups and either identical ( symmetrical) or different ( unsymmetrical) lipophilic tailgroups is described. Transfection activity is found to depend critically upon the structural elements present.
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