Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 2, Issue 20, Pages 2885-2887Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b411626g
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9-Mer DNA sequences containing 2'-N-methyl-2'-N-(pyren-1-ylmethyl)-2'-amino-DNA monomers display significantly increased affinity towards DNA complements whereas the corresponding 2'-amino-DNA monomer has a detrimental effect on duplex stability. These effects are efficiently reversed by incorporation of four LNA nucleotides inducing a B-DNA to A-DNA conformational change.
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