Journal
CARDIOVASCULAR RESEARCH
Volume 96, Issue 3, Pages 363-371Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvs276
Keywords
Restenosis; Constrictive remodelling; Adaptive remodelling; ECM; EEL
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Funding
- Public Health Service from National Heart, Lung, and Blood Institute [R01-HL-068673]
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It has been appreciated over the past two decades that arterial remodelling, in addition to intimal hyperplasia, contributes significantly to the degree of restenosis that develops following revascularization procedures. Remodelling appears to be an adventitia-based process that is contributed to by multiple factors including cytokines and growth factors that regulate extracellular matrix or phenotypic transformation of vascular cells including myofibroblasts. In this review, we summarize the currently available information from animal models as well as clinical investigations regarding arterial remodelling. The factors that contribute to this process are presented with an emphasis on potential therapeutic methods to enhance favourable remodelling and prevent restenosis.
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