Journal
CARDIOVASCULAR RESEARCH
Volume 94, Issue 2, Pages 197-205Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvr358
Keywords
Autophagy; Myocardial ischaemia; Myocardial reperfusion; Reperfusion injury
Categories
Ask authors/readers for more resources
Autophagy is the tightly orchestrated cellular ohousekeeping' process responsible for the degradation and disposal of damaged and dysfunctional organelles and protein aggregates. In addition to its established basal role in the maintenance of normal cellular phenotype and function, there is growing interest in the concept that targeted modulation of autophagy under conditions of stress (most notably, ischaemia/reperfusion) may represent an adaptive mechanism and render the myocardium resistant to ischaemia/reperfusion injury. Our aims in this review are to: (i) provide a balanced overview of the emerging hypothesis that perturbation of autophagy may serve as a novel, intriguing, and powerful cardioprotective treatment strategy and (ii) summarize the controversies and challenges in exploiting autophagy as a therapeutic target for ischaemia/reperfusion injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available