Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 2, Issue 19, Pages 2798-2801Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b408485c
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Incorporation of photo-switchable amino acids into peptides and proteins offers prospects for the control of complex biochemical processes using light. Currently, only a few photo-switchable amino acids are known. We report the design and synthesis of a novel hemithioindigo-based amino acid and its incorporation into the model ion channel gramicidin. Photoisomerization of the hemithioindigo moiety between E and Z isomeric forms is shown to modulate ionic current through the channel in a predictable way. This new amino acid thus expands the possibilities for photo-control in diverse systems.
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