Journal
CARDIOVASCULAR RESEARCH
Volume 90, Issue 3, Pages 430-440Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvr097
Keywords
Non-coding RNA; ncRNA; Vascular biology; Epigenetics; Gene regulation
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Funding
- Leducq Foundation Transatlantic Network of Excellence
- Sigrid Juselius fellowship
- Fondation Leducq
- Academy of Finland
- ASLA-Fulbright
- Finnish Foundation for Cardiovascular Research
- Finnish Cultural Foundation
- Orion-Farmos Research Foundation
- NIH/NIGMS [T32 GM008666, 5 T32 GM007198-37]
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Genome-wide studies have revealed that mammalian genomes are pervasively transcribed. This has led to the identification and isolation of novel classes of non-coding RNAs (ncRNAs) that influence gene expression by a variety of mechanisms. Here we review the characteristics and functions of regulatory ncRNAs in chromatin remodelling and at multiple levels of transcriptional and post-transcriptional regulation. We also describe the potential roles of ncRNAs in vascular biology and in mediating epigenetic modifications that might play roles in cardiovascular disease susceptibility. The emerging recognition of the diverse functions of ncRNAs in regulation of gene expression suggests that they may represent new targets for therapeutic intervention.
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