Journal
CARDIOVASCULAR RESEARCH
Volume 93, Issue 4, Pages 605-613Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvr268
Keywords
MicroRNA; Inflammation; Cardiovascular disease; Metabolic syndrome; Ageing
Categories
Funding
- Netherlands Organization for Scientific Research [016.096.126, 91796338]
- Netherlands Genomics Initiative [93519017]
- Netherlands Heart Foundation [NHS 2009B025, NHS 2007B036, 2008B011]
- Research Foundation - Flanders (FWO) [1183211N, 1167610N, G074009N]
- European Union [FP7-HEALTH-2010, FP7-HEALTH-2011]
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With a progressively growing elderly population, ageing-associated pathologies such as cardiovascular diseases are becoming an increasing economic, social, and personal burden for Western societies. Interestingly, all ageing-associated diseases share a common denominator: inflammation. Recently, microRNAs were shown to be implicated in the full range of processes of ageing, inflammation, and cardiovascular diseases. This review focuses on their role in cardiovascular diseases with emphasis on their implication in the inflammatory processes that accompany heart failure, atherosclerosis, coronary artery disease, and finally obesity and diabetes as components of the ageing-associated metabolic syndrome.
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