Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 113, Issue 1, Pages 11-28Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2003.10.047
Keywords
eosinophil; gastrointestinal; inflammation; pathogenesis; therapy
Categories
Funding
- NIAID NIH HHS [AI45898, R01 AI42242] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI045898, R01AI045898, R01AI042242] Funding Source: NIH RePORTER
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Primary eosinophilic gastrointestinal disorders are defined as disorders that selectively affect the gastrointestinal tract with eosinophil-rich inflammation in the absence of known causes for eosinophilia (eg, drug reactions, parasitic infections, and malignancy). These disorders include eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, eosinophilic enteritis, and eosinophilic colitis and are occurring with increasing frequency. Significant progress has been made in elucidating that eosinophils are integral members of the gastrointestinal mucosal immune system and that eosinophilic gastrointestinal disorders are primarily polygenic allergic disorders that involve mechanisms that fall between pure IgE-mediated and delayed T(H)2-type responses. Preclinical studies have identified a contributory role for the cytokine IL-5 and the eotaxin chemokines, providing a rationale for specific disease therapy. An essential question is to determine the cellular and molecular basis for each of these clinical problems and the best treatment regimen, which is the main subject of this review.
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