Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 2, Issue 11, Pages 1651-1658Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b402431a
Keywords
-
Categories
Funding
- NCI NIH HHS [U19CA-52995] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [U19CA052995] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to > 100 muM.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
