KF-alumina catalyzed one-pot synthesis of pyrido[2,3-d]pyrimidine derivatives

A series of pyrido[2,3-d]pyrimidine derivatives was synthesized by the reaction of arylaldehyde, malononitrile. and 4-amino-2,6-dihydroxylpyrimidine in ethyl alcohol at 80degreesC catalyzed by KF-Al2O3. Compared with other synthetic methods, this new method has the advantage of easier workup, milder reaction conditions, and good yields.