Journal
SYNTHETIC COMMUNICATIONS
Volume 34, Issue 23, Pages 4331-4338Publisher
TAYLOR & FRANCIS INC
DOI: 10.1081/SCC-200039392
Keywords
pyrido[2,3-d]pyrimidine; aromatization; KF-Al2O3 synthesis
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A series of pyrido[2,3-d]pyrimidine derivatives was synthesized by the reaction of arylaldehyde, malononitrile. and 4-amino-2,6-dihydroxylpyrimidine in ethyl alcohol at 80degreesC catalyzed by KF-Al2O3. Compared with other synthetic methods, this new method has the advantage of easier workup, milder reaction conditions, and good yields.
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