Journal
CARDIOVASCULAR RESEARCH
Volume 88, Issue 2, Pages 229-240Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvq239
Keywords
Mitochondria; Diabetes; Heart; Metabolism
Categories
Funding
- German Research Foundation (DFG)
- National Institutes of Health [UO1HL70525, UO1 HL087947, RO1 HL70070, RO1 HL73167]
- Juvenile Diabetes Research Foundation
- American Diabetes Association
- American Heart Association
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Diabetes mellitus increases the risk of developing cardiovascular diseases such as coronary artery disease and heart failure. Studies have shown that the heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Although the cause of this increased heart failure risk is multifactorial, increasing evidence suggests that derangements in cardiac energy metabolism play an important role. In particular, abnormalities in cardiomyocyte mitochondrial energetics appear to contribute substantially to the development of cardiac dysfunction in diabetes. This review will summarize these abnormalities in mitochondrial function and discuss potential underlying mechanisms.
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