4.1 Article

The chemoselective alkynylation of dihaloquinolines by the Sonogashira-Hagihara reaction

Journal

RUSSIAN CHEMICAL BULLETIN
Volume 53, Issue 1, Pages 189-193

Publisher

SPRINGER
DOI: 10.1023/B:RUCB.0000024849.57521.49

Keywords

alkynylation; dihaloquinolines; Sonogashira-Hagihara reaction

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Conditions for the regioselective Sonogashira-Hagihara alkynylation of 4-chloro-6-iodo(bromo)quinolines were found and 6-alkynyl-4-chloroquinolines were obtained in 90-100% yields.

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