Journal
CARDIOVASCULAR RESEARCH
Volume 83, Issue 2, Pages 247-261Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvp033
Keywords
Cardioprotection; Ischaemic preconditioning; Ischaemic postconditioning; Myocardial infarction; Myocardial ischaemia; Reperfusion; Ageing
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The present review discusses changes in protein expression and cell signalling important to ischaemia/reperfusion injury with myocardial ageing. The efficacy of cardioprotective manoeuvres, e.g. ischaemic pre and postconditioning in aged organs and animals will be discussed, and the development of strategies aimed to antagonize the age-induced loss of protection will be addressed.
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