Journal
CYTOGENETIC AND GENOME RESEARCH
Volume 105, Issue 2-4, Pages 240-250Publisher
KARGER
DOI: 10.1159/000078195
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Funding
- NCI NIH HHS [P30 CA34196] Funding Source: Medline
- NCRR NIH HHS [RR015253] Funding Source: Medline
- NHGRI NIH HHS [HG00330, HG02273] Funding Source: Medline
- NICHD NIH HHS [HD37102] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD037102] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [P30CA034196] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [R24RR015253] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [P01HG000330, P41HG000330] Funding Source: NIH RePORTER
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The transcriptome of the 2-cell mouse embryo was analyzed to provide insight into the molecular networks at play during nuclear reprogramming and embryonic genome activation. Analysis of ESTs from a 2-cell cDNA library identified nearly 4,000 genes, over half of which have not been previously studied. Transcripts of mobile elements, especially those of LTR retrotransposons, are abundantly represented in 2-cell embryos, suggesting their possible role in introducing genomic variation, and epigenetic restructuring of the embryonic genome. Analysis of Gene Ontology of the 2-cell-stage expressed genes outlines the major biological processes that guide the oocyte-to-embryo transition. These results provide a foundation for understanding molecular control at the onset of mammalian development. Copyright (C) 2004 S. Karger AG, Basel.
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