Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 75, Issue 1, Pages 27-33Publisher
WILEY
DOI: 10.1189/jlb.0703304
Keywords
surfactant proteins A and D; mannan-binding lectin; C-type lectin; collagenous regions
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The collectins are a small family of secreted glycoproteins that contain C-type lectin domains and collagenous regions. They have an important function in innate immunity, recognizing and binding to microorganisms via sugar arrays on the microbial surface. Their function is to enhance adhesion and phagocytosis of microorganisms by agglutination and opsonization. In the lung, two members of the collectin family, surfactant proteins A and D, are major protein constituents of surfactant. Another collectin, mannan-binding lectin, is also present in the upper airways and buccal cavity and may protect against respiratory infections. Recent work has shown that collectins have roles in resistance to allergy and in the control of apoptosis and clearance of apoptotic macrophage in the lung.
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