Journal
CYTOGENETIC AND GENOME RESEARCH
Volume 107, Issue 3-4, Pages 249-255Publisher
KARGER
DOI: 10.1159/000080602
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Funding
- NICHD NIH HHS [P01 HD024605, R01 HD23141] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [P01HD024605] Funding Source: NIH RePORTER
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We combined immunostaining and fluorescence in situ hybridization (FISH) methodology to directly examine meiotic exchanges in over 2,000 pachytene stage spermatocytes from 25 individuals. Our results indicate that, on average, there are about 50 exchanges per cell and that, with the exception of the acrocentric chromosomes, all chromosome arms harbor at least one exchange. We also identified significant among-individual variation in the mean number of exchanges, with an approximate 20% difference between individuals with low and those with high exchange frequencies. Copyright (C) 2004 S. Karger AG, Basel.
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