Journal
PHYTOCHEMISTRY
Volume 65, Issue 1, Pages 99-106Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2003.09.015
Keywords
Stemona cf. pierrei; stemonaceae; stilbenoids; dihydrophenanthrenes; stemanthrenes A-C; dihydrostilbenes; stilbostemin G; antifungal; bioautography; microdilution; protostemonine; stemonine; pyrrolo[1,2-a]azepines; stemona alkaloids
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Three new dihydrophenanthrenes, stemanthrenes A-C, along with the new dihydrostilbene stilbostemin G were isolated and identified from the underground parts of Stemona cf. pierrei together with the known pinosylvin, 4'-methylpinosylvin, dihydropinosylvin, stilbostemins B, D, and E as well as the pyrrolo[1,2-a]azepine alkaloids protostemonine and stemonine. The structures of all new stilbenoids, elucidated by NMR analyses, showed a common substitution pattern for aromatic ring A and characteristic C-methylations for ring B. The trivial name racemosol, previously reported for S. collinsae, was renamed to stemanthrene D due to its priority for another compound. Bioautographic tests on TLC plates with Cladosporium herbarum displayed high antifungal activity for compounds with an unsubstituted aromatic ring A, e.g. pinosylvin, but only weak effects for the higher substituted stilbostemin G and stemanthrenes A-C. Similar results were obtained by germ tube inhibition of five microfungi using 2-fold serial broth dilutions determined by a microplate reader. Because of weak inhibition and chemical instability of stemanthrenes, no EC50 and EC90 values could be calculated. (C) 2003 Elsevier Ltd. All rights reserved.
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