Journal
CARDIOVASCULAR RESEARCH
Volume 79, Issue 4, Pages 553-561Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvn151
Keywords
microRNAs; transcription factors; epigenetic gene regulation; cell differentiation
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Funding
- Italian Association for Cancer Research (AIRC)
- Italian Ministry for Education
- University and Research (PRIN)
- 'Sapienza' University of Rome
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Characterization of regulatory mechanisms affecting microRNA (miRNA) expression and activity is providing novel clues for the identification of genes and complex regulatory circuits that determine cell and tissue specificity. Here, we review the molecular events leading to miRNA biogenesis and activity, focusing above all on endogenous and epigenetic transcriptional networks involving miRNA in early development, cellular lineage specification/differentiation of nervous, skeletal and cardiac muscle tissues and in haematopoiesis, as the de-regulation of such networks may be relevant to disease pathogenesis.
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