Journal
CARDIOVASCULAR RESEARCH
Volume 81, Issue 1, Pages 11-19Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvn248
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Funding
- British Heart Foundation [CH/92013]
- St George's Hospital Charitable Foundation
- Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain
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The crucial role of T cells in atherosclerosis and coronary artery disease (CAD) has been highlighted by recent observations. Helper CD4(+) T cells can both aggravate or attenuate the atherogenic process and the development of CAD. CD4(+)CD28(null) T cells are an unusual subset of helper cells which expand and have deleterious effects in CAD. In this review, we discuss the current issues on the generation of CD4(+)CD28(null) T cells and focus on their phenotypic and functional characteristics relevant to the development of cardiovascular events. The possible effects of the present day therapies for CAD on the CD4(+)CD28(null) T cells are also explored. Targeting the CD4(+)CD28(null) T cell subset in CAD could provide novel therapeutic strategies to prevent acute life-threatening coronary events.
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