Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 137, Issue 1, Pages 64-66Publisher
SPRINGER
DOI: 10.1023/B:BEBM.0000024389.16247.0a
Keywords
chronic obstructive; pulmonary disease; allele variants of metalloproteinase 9; glutathione-S transferase M1
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The incidence of allele variants of glutathione-S transferase M1 xenobiotic detoxification gene and matrix metalloproteinase 9 gene was analyzed in patients with chronic obstructive pulmonary disease. A strict gene-gene interaction between these two genes in the formation of hereditary predisposition to this disease was first demonstrated. The combination of glutathione-S transferase M1 genotype 0/0 and matrix metalloproteinase 9 mutant allele (-15621) is a risk factor for chronic obstructive pulmonary disease (OR-7.7).
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