Journal
JOURNAL OF NATURAL PRODUCTS
Volume 67, Issue 1, Pages 49-53Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np030215x
Keywords
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Funding
- NATIONAL CANCER INSTITUTE [U19CA053001, U01CA053001, R01CA012623] Funding Source: NIH RePORTER
- NCI NIH HHS [CA 53001, CA 12623] Funding Source: Medline
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Two new cytotoxins have been isolated from a species of marine cyanobacterium belonging to the genus Symploca that was collected in Guam. These new compounds, micromide (1) and guamamide (2), were accompanied by the known lipopeptides apramides A (3), B (4), and G (5). The planar structures of both alkaloids were elucidated by standard 2D NMR techniques, and the configurations of the amino acid-derived units in 1 were determined by chiral HPLC. The stereochemistry of the beta-methoxyhexanoic acid in 1 was determined by derivatization with methyl D-mandelate, after acid hydrolysis, and comparison with synthetic standards.
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