Journal
LASERS IN SURGERY AND MEDICINE
Volume 35, Issue 4, Pages 269-275Publisher
WILEY
DOI: 10.1002/lsm.20098
Keywords
carcinoma; imaging; leukoplakia; non-invasive diagnostics; oral diagnosis
Categories
Funding
- NATIONAL CANCER INSTITUTE [R21CA087527, R01CA091717] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR001192] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000293] Funding Source: NIH RePORTER
- NCI NIH HHS [R021 CA 87527-01, CA 91717] Funding Source: Medline
- NCRR NIH HHS [RR 01192] Funding Source: Medline
- NIBIB NIH HHS [EB 00293] Funding Source: Medline
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Background and Objective: Oral cancer results in 10,000 U.S. deaths annually. Improved highly sensitive diagnostics allowing early detection of oral cancer would benefit patient survival and quality of life. Objective was to investigate in vivo non-invasive optical coherence tomography (OCT) techniques for imaging and diagnosing neoplasia-related epithelial, sub-epithelial changes throughout carcinogenesis. Study Design/Materials and Methods: In the standard hamster cheek pouch model for oral carcinogenesis (n = 36), in vivo OCT was used to image epithelial and sub-epithelial change. OCT- and histopathology-based diagnoses on a scale of 0 (healthy) to 6 (squamous cell carcinoma, SCC) were performed at all stages throughout carcinogenesis by two blinded investigators. Results: Epithelial, sub-epithelial structures were clearly discernible using OCT. OCT diagnosis agreed with the histopathological gold standard in 80% of readings. Conclusion: In vivo OCT demonstrates excellent potential as a diagnostic tool in the oral cavity. (C) 2004 Wiley-Liss, Inc.
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