Journal
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
Volume 43, Issue 1, Pages 63-70Publisher
ELSEVIER SCIENCE INC
DOI: 10.1097/00004583-200401000-00015
Keywords
major depressive disorder; children; adolescents; longitudinal course
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Funding
- NIMH NIH HHS [5 P01 MH41712] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [P01MH041712] Funding Source: NIH RePORTER
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Objective: To simultaneously and prospectively compare the clinical presentation, course, and parental psychiatric history between children and adolescents with major depressive disorder. Method: A group of prepubertal children (n = 46) and postpubertal adolescents (n = 22) were assessed with structured interviews for psychopathology and parental psychiatric history and followed once every 2 years for approximately 5 years. Results: With the exception of more depressive melancholic symptoms in the adolescents, both groups had similar depressive symptomatology, duration (average 17 months), severity of the index episode, rates of recovery (85%) and recurrence (40%), comorbid disorders, and parental psychiatric history. Female sex, increased guilt, prior episodes of depression, and parental psychopathology were associated with worse longitudinal course. Conclusions: In general, major depressive disorder is manifested similarly in children and adolescents, and both groups have a protracted clinical course and high family loading for psychiatric disorders.
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