Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 9, Issue -, Pages 277-282Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/1145
Keywords
Parkinson's disease; MPTP; inflammation; blood vessels; glia; iron; review
Categories
Funding
- NINDS NIH HHS [R01-NS40578-01] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS040578] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Blood vessels are the way for nutrients present outside the brain to gain access into the cerebral parenchyma. When neurons are diseased, for example by toxin exposure, reactive glial cells secrete local factors that induce microangiogenesis, probably as part of a spontaneous neuroprotective mechanism related to the increased metabolic demand. In Parkinson's disease (PD) and non human primate models of PD, nigral degeneration is associated with gliosis and microvascular proliferation. Interestingly, microangiogenesis also facilitates the entrance into the brain parenchyma of neurotoxins and harmful cytokine-releasing blood cells, both of which have been linked to neuronal cell death in PD. In the present review we discuss the potential implications of vascular-related phenomena with mechanisms of neuronal damage in PD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available