Journal
CARDIOVASCULAR PATHOLOGY
Volume 18, Issue 4, Pages 198-204Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.carpath.2008.05.003
Keywords
Endomyocardial biopsy; Acute cellular rejection; Cardiac transplant rejection; Grading; Interobserver reproducibility; 2004 ISHLT scale
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We compared the interobserver reproducibility of the 1990 and 2004 International Society for Heart and Lung Transplantation (ISHLT) grading system for cardiac rejection. The 2004 ISHLT grading system for cardiac allograft rejection did not improve reproducibility partly due to pathologists' disagreement in diagnosing Grades 1B/1R and 3A/2R rejection. To achieve better reproducibility, better criteria for defining 1B/1R vs. 3A/2R rejection and markers of myocyte injury are needed. (C) 2009 Elsevier Inc. All rights reserved.
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