Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 9, Issue -, Pages 786-796Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/1278
Keywords
multiple sclerosis; MS; B cells; antibodies; oligoclonal bands; review; CNS; central nervious system; neurologic disease; review
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS041549, P01NS032623] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS 32623, NS 41549, P01 NS032623, R01 NS041549, R01 NS041549-03] Funding Source: Medline
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The most common laboratory abnormality in multiple sclerosis (MS) is an increased amount of cerebrospinal fluid IgG and the presence of oligoclonal bands. Despite studies of the humoral response that suggest the involvement of an infectious agent or autoantigen in disease, the major targets of the oligoclonal response are still unknown. Identification of these targets will reveal valuable insights into the cause and pathogenesis of MS and is likely to lead to effective treatment.
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