Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 256, Issue 1-2, Pages 107-115Publisher
SPRINGER
DOI: 10.1023/B:MCBI.0000009862.17396.8d
Keywords
mitochondrion; outer membrane; apoptosis; isoforms; metabolism
Categories
Funding
- NINDS NIH HHS [NS 42025] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS042025] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The mitochondrial outer membrane is not just a barrier but a site of regulation of mitochondrial function. The VDAC family of proteins are the major pathways for metabolite flux through the outer membrane. These can be regulated in a variety of ways and the integration of these regulatory inputs allows mitochondrial metabolism to be adjusted to changing cellular conditions. This includes total blockage of the flux of anionic metabolites leading to permeabilization of the outer membrane to small proteins followed by apoptotic cell death.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available