Journal
CARDIOVASCULAR RESEARCH
Volume 61, Issue 1, Pages 11-21Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.cardiores.2003.09.033
Keywords
apoptosis; atherosclerosis; coronary disease; restenosis
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL063911, K24HL069840] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL63911-04, K24 HL69840-01] Funding Source: Medline
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During recent years, the ubiquitin-proteasome system has become known as the major pathway of non-lysosomal degradation of intracellular proteins, involving two sequential steps. In the first step, multiple moieties of ubiquitin are covalently bound to target proteins to be recognized and degraded by the multi-enzymatic proteasome complex in the second step. In addition to the elimination of damaged and unneeded proteins, this system fulfills an important function in the regulation of cellular mediators in various biological pathways. Foremost, these biological pathways include inflammation, cell proliferation, and apoptosis, all of which constitute important characteristics of atherosclerosis. Indeed, recent experimental evidence supports a potential involvement of the ubiquitin-proteasome system in the initiation, progression, and complication stage of atherogenesis. This review summarizes recent findings regarding the ubiquitin-proteasome system in cardiovascular diseases and discusses the potential use of proteasome inhibitors in cardiovascular therapy. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
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