Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 61, Issue 1, Pages 4-9Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-003-3262-x
Keywords
apolipoprotein B; atherosclerosis; proteoglycan; retention; glycos aminoglycan; transgenic mice
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Atherosclerosis is a multifactorial disease whose pathogenesis is still unclear. Mounting evidence, however, supports the concept that subendothelial retention of apoB100-containing lipoproteins is the initiating event in atherogenesis. Subsequently, a series of biological responses to this retained material leads to specific molecular and cellular processes that promote lesion formation.
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