Journal
NEUROPHARMACOLOGY
Volume 47, Issue -, Pages 300-311Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2004.07.013
Keywords
opioid receptor; receptor signaling; transcription regulation; opioid tolerance
Categories
Funding
- NIDA NIH HHS [K05-DA00513, K02-DA13926, K05-DA70554, DA15091, DA00564, DA01583, DA07339, DA11190, DA11806] Funding Source: Medline
- NIDDK NIH HHS [DK54733, DK60521] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK060521, R01DK054733] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA011190, K02DA013926, R01DA000564, R01DA007339, K05DA070554, P01DA015091, R37DA001583, R01DA001583, P50DA011806, K05DA000513] Funding Source: NIH RePORTER
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Drug addiction has great social and economical implications. In order to resolve this problem, the molecular and cellular basis for drug addiction must be elucidated. For the past three decades, our research has focused on elucidating the molecular mechanisms behind morphine tolerance and dependence. Although there are many working hypotheses, it is our premise that cellular modulation of the receptor signaling, either via transcriptional or post-translational control of the receptor, is the basis for morphine tolerance and dependence. Thus, in the current review, we will summarize our recent work on the transcriptional and post-translational control of the opioid receptor, with special emphasis on the L-opioid receptor, which is demonstrated to mediate the in vivo functions of morphine. (C) 2004 Elsevier Ltd. All rights reserved.
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