Infant feeding practices of women in a perinatal HIV-1 Prevention Study in Nairobi, Kenya

Objective: To determine feeding practices and nutritional status of infants born to HIV-1-infected women. Methods: Feeding plans and practices were evaluated by questionnaires and focus group discussions. Infants were weighed at I and 6 weeks and tested for HIV-1 at 6 weeks. Results: Of 128 women seen after delivery, 111 completed the study. Mothers who planned to breast feed were more likely to feed their infants as planned (86% vs. 55%; P < 0.001). Women opted to breast feed due to financial constraints, partner influence, and fear of losing confidentiality. Women who reported that their partners were willing to have HIV-1 testing were less likely to be breast feeding at 6 weeks (odds ratio [OR] = 0.3, 95% confidence interval [CI]: 0.1-0.8; P = 0.01). At 6 weeks, more infants were mixed fed (31% vs. 21%; P = 0.05) than at 1 week. Lower infant weight at 6 weeks was associated with not breast feeding (P = 0.001), HIV-1 infection (P = 0.05), birth weight < 3000 g (P = 0.01), maternal employment (P = 0.02), and paying < $12.5 per month in house rent (among infants not breast fed; P = 0.05). Conclusions: Replacement feeding was difficult, particularly without partner support in HIV-1 testing. Mixed feeding was common and increased by 6 weeks. Mothers oflow socioeconomic status who opt not to breast feed require support to avoid nutritional compromise of infants.